Peroxynitrite-mediated oxidative protein modifications
نویسندگان
چکیده
منابع مشابه
Protein Tyrosine Nitration and Thiol Oxidation by Peroxynitrite—Strategies to Prevent These Oxidative Modifications
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase an...
متن کاملPeroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology.
Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation of protein, lipid, and nucleic acid. We recently have identified porphyrin derivatives capable o...
متن کاملProtein Oxidative Modifications: Beneficial Roles in Disease and Health.
Protein oxidative modifications, also known as protein oxidation, are a major class of protein posttranslational modifications. They are caused by reactions between protein amino acid residues and reactive oxygen species (ROS) or reactive nitrogen species (RNS) and can be classified into two categories: irreversible modifications and reversible modifications. Protein oxidation has been often as...
متن کاملModifications of tyrosine and catecholamines by peroxynitrite, nitrite and nitrate.
At pH 7.0 in non-"deaired" potassium phosphate buffer, the reactions of L-tyrosine, L-dopa, dopamine, L-norepinephrine, and L-epinephrine with peroxynitrite (PN) or nitrite, generated colored products. These products displayed not only unique colors and patterns of mobility on silica thin layer chromatographic plates, but also varied increase of absorbance between 400 and 540 nm. In particular,...
متن کاملInvited Review Biological significance of nitric oxide-mediated protein modifications
Gow, Andrew J., Christiana R. Farkouh, David A. Munson, Michael A. Posencheg, and Harry Ischiropoulos. Biological significance of nitric oxidemediated protein modifications. Am J Physiol Lung Cell Mol Physiol 287: L262– L268, 2004; 10.1152/ajplung.00295.2003.—Nitric oxide (NO), despite an apparently simple diatomic structure, has a wide variety of functions in both physiology and pathology and ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1995
ISSN: 0014-5793
DOI: 10.1016/0014-5793(95)00307-u